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Why Do I Feel Tired All the Time? Common Lifestyle Factors

Home / Live Healthy / Ailments and Remedies / Why Do I Feel Tired All the Time? Common Lifestyle Factors
  • SVK Herbal Vi
  • July 8, 2026

You slept eight hours last night. You had your coffee this morning. Yet by 10 AM, you are already counting down to the couch.

Persistent fatigue is one of the most common complaints in modern clinical practice. A National Sleep Foundation poll found that Americans report feeling sleepy on three or more days every week – and the consequences go far beyond inconvenience. Chronic tiredness impairs concentration, mood, immune function, and long-term metabolic health in ways that compound quietly over time.

The critical distinction most people miss is this: fatigue is a symptom, not a diagnosis. It is your body’s way of signaling that something in its operating environment is out of balance. In the majority of cases – particularly in otherwise healthy adults – that imbalance is rooted in lifestyle factors that are entirely addressable.

This article breaks down the most common lifestyle-driven causes of chronic tiredness, the biology behind each one, and the evidence-based steps you can take to recover your energy at a cellular level.

Table of Contents

Toggle
  • The Biology of Fatigue: Why Lifestyle Matters More Than You Think
  • Common Lifestyle Factors That Cause Chronic Fatigue
  • The Role of Traditional Medicine in Addressing Chronic Fatigue
  • A Practical Diagnostic Approach: Where to Start
  • When To See a Doctor
  • The Bottom Line
  • Frequently Asked Questions (FAQs)

The Biology of Fatigue: Why Lifestyle Matters More Than You Think

Energy production in the human body is not passive. Every cell runs on ATP (adenosine triphosphate) – a molecule produced primarily in the mitochondria through a chain of biochemical processes that depend on oxygen, glucose, micronutrients, hormonal balance, and adequate recovery. When any link in that chain is disrupted – by poor sleep, nutritional gaps, chronic stress, or sedentary behavior – ATP output falls, and the result is felt as tiredness, brain fog, and physical heaviness.

Understanding this matters because it reframes fatigue from an inevitable state to a solvable problem. The British Heart Foundation notes that in most cases of persistent tiredness, a clear cause can be identified and treated. The first step is knowing where to look.

Common Lifestyle Factors That Cause Chronic Fatigue

1. Poor Sleep Quality – The Foundation of Everything

Insufficient or disrupted sleep is the single most prevalent cause of daytime fatigue. But it is not just about hours. Sleep quality – the depth and architecture of the sleep you get – matters as much as duration. During deep NREM sleep, the brain clears metabolic waste via the glymphatic system, consolidates memory, resets pain thresholds, and restores hormonal balance. During REM sleep, emotional regulation and neurotransmitter synthesis occur. Shortchange either phase and no amount of extra time in bed fully compensates.

Circadian rhythm disruption – caused by inconsistent bedtimes, late-night screens, shift work, or excessive weekend sleep-ins – is an increasingly recognized driver of chronic fatigue. The circadian clock governs cortisol, melatonin, insulin sensitivity, and mitochondrial activity. When it drifts out of alignment with the light-dark cycle, energy metabolism becomes erratic and daytime alertness suffers. Find out more about circadian rhythm sleep disorders and their broader impact on health at SVKHerbal.

What to do:

  • Maintain a consistent bedtime and wake time – including weekends
  • Target 7-9 hours of uninterrupted sleep
  • Eliminate screens at least 60 minutes before bed – blue light suppresses melatonin production
  • Keep the bedroom cool (18-20°C), dark, and quiet
  • Avoid alcohol within 3 hours of sleep – it fragments REM architecture and worsens sleep quality

2. Sedentary Lifestyle – The Energy Paradox

It seems counterintuitive, but physical inactivity is a major cause of fatigue. Prolonged sitting reduces cardiac output, slows venous return, lowers mitochondrial density in muscle cells, and allows inflammatory cytokines to accumulate unchecked. The body is designed for movement. Without it, the systems that generate energy atrophy.

Regular aerobic exercise, by contrast, is one of the most powerful fatigue-reduction interventions available. It increases mitochondrial biogenesis – literally building more energy-producing machinery inside muscle cells. It improves sleep quality, reduces cortisol, increases BDNF (brain-derived neurotrophic factor), and enhances cerebral blood flow – all of which translate directly into more sustainable daytime energy.

A study published in Psychotherapy and Psychosomatics found that sedentary individuals who began a moderate exercise program reported a 65% reduction in fatigue compared to control groups. The dose required is not extreme – 30 minutes of brisk walking five days a week is sufficient to produce measurable energy improvements within weeks.

What to do:

  • Start with 20-30 minutes of moderate aerobic activity daily – walking, swimming, or cycling
  • Break up prolonged sitting with a 5-minute walk every 45-60 minutes
  • Incorporate 2-3 resistance training sessions per week to build mitochondrial density
  • Avoid the “weekend warrior” pattern – consistency matters more than intensity

3. Nutritional Deficiencies – The Invisible Energy Drain

Chronic fatigue driven by nutritional deficiencies is extraordinarily common and frequently overlooked. People can eat sufficient calories while remaining critically deficient in the micronutrients that power cellular energy production. The most clinically significant culprits are:

Iron Deficiency

Iron is the mineral at the center of hemoglobin – the protein that carries oxygen in the blood. Without sufficient iron, hemoglobin production falls, red blood cells become smaller and less functional, and oxygen delivery to every cell in the body is compromised. The result is a deep, cellular-level fatigue that no amount of rest resolves. The WHO estimates that iron deficiency affects approximately 2 billion people globally, making it the world’s most prevalent nutritional deficiency.

Critically, suboptimal iron status – a ferritin level too low to optimally support energy metabolism, even before frank anemia develops – is associated with persistent fatigue, cold hands and feet, poor concentration, and reduced exercise tolerance. Find out more about the signs of iron deficiency in this article on SVKHerbal.

Vitamin B12 Deficiency

Vitamin B12 is essential for red blood cell formation, myelin sheath maintenance around nerve fibers, and neurotransmitter synthesis. Deficiency produces a megaloblastic anemia – large, dysfunctional red cells – along with neurological symptoms including fatigue, tingling, brain fog, and mood disruption. B12 deficiency is particularly prevalent in older adults, vegetarians and vegans, and those taking metformin or proton pump inhibitors long-term.

Vitamin D Deficiency

Vitamin D receptors are present in virtually every tissue in the body, including the mitochondria of skeletal muscle cells. Deficiency impairs mitochondrial function directly and is associated with fatigue, muscle weakness, and depressed mood. The British Heart Foundation notes vitamin D deficiency as one of the most common reversible causes of chronic tiredness – affecting 1 in 5 adults in northern latitudes.

Protein Deficiency

Protein provides the amino acid building blocks for neurotransmitters (serotonin, dopamine, norepinephrine), enzymes, hormones, and the structural proteins of every cell. Without adequate dietary protein, neurotransmitter synthesis falters, blood sugar regulation becomes erratic, and the body progressively loses lean muscle mass. The result is fatigue that has both physical and psychological dimensions – weakness, poor motivation, and cognitive fog. Adults generally require 0.8-1.2g of protein per kilogram of body weight daily, with requirements increasing with age, activity level, and physiological stress. Find out more about protein deficiency symptoms and their impact in this article on SVKHerbal.

What to do:

  • Request a blood panel covering ferritin, serum B12, vitamin D (25-OH), and full blood count
  • Prioritize iron-rich foods – red meat, liver, oysters, lentils, and dark leafy greens. Find a comprehensive guide to iron-rich foods for daily energy on SVKHerbal
  • Pair plant-based iron sources with vitamin C to enhance non-heme iron absorption
  • Ensure protein at every meal – eggs, legumes, fish, poultry, tofu, or quality supplements
  • Consider vitamin D supplementation if sun exposure is limited – particularly in winter months

4. Chronic Stress and HPA Axis Dysregulation

Chronic psychological stress is one of the most direct and underappreciated causes of persistent fatigue. When stress is sustained rather than episodic, the hypothalamic-pituitary-adrenal (HPA) axis remains chronically activated, maintaining cortisol at elevated levels. Over time, this exhausts the adrenal response capacity, disrupts sleep architecture, depletes neurotransmitter precursors, and drives systemic inflammation – all of which compound into profound tiredness.

The Healthline clinical review notes that chronic stress can lead to “stress-related exhaustion disorder” – a medically recognized condition in which psychological and physical exhaustion coexist and reinforce each other. Chronic stress also causes structural changes in the brain – reducing hippocampal volume and disrupting prefrontal cortex function – which impairs both cognitive performance and the capacity to regulate emotional responses to stressors, creating a self-perpetuating cycle.

What to do:

  • Practice daily diaphragmatic breathing – 5-10 minutes activates the parasympathetic nervous system and measurably lowers cortisol
  • Incorporate mindfulness meditation – consistent practice reduces inflammatory cytokines and stress-driven fatigue
  • Set firm boundaries around working hours and “always-on” digital culture
  • Explore adaptogenic herbs such as Dangshen (Codonopsis pilosula) – shown to reduce fatigue and improve HPA axis resilience

5. Poor Diet Quality and Blood Sugar Instability

What you eat has a direct and rapid effect on your energy levels – not just through micronutrient content, but through the moment-to-moment stability of your blood glucose. Diets high in refined carbohydrates and processed sugars produce sharp insulin spikes followed by reactive hypoglycemia – the classic “food coma” or mid-afternoon energy crash that millions of people experience as a fixed feature of daily life. In reality, it is a dietary pattern problem with a clear solution.

Highly processed foods are also disproportionately low in the micronutrients required for mitochondrial energy production – B vitamins, magnesium, zinc, and CoQ10 – while simultaneously elevating oxidative stress markers that impair cellular energy output. A 2019 study published in Nutrients found that individuals following high-fat, low-nutrient diets combined with sedentary lifestyles showed significantly elevated oxidative stress biomarkers – directly linked to fatigue, muscle pain, and cognitive impairment.

What to do:

  • Replace refined carbohydrates with complex carbohydrates – oats, quinoa, legumes, and sweet potato – which produce stable, sustained glucose release
  • Eat protein at every meal to blunt the glucose response and sustain dopamine and serotonin synthesis
  • Prioritize magnesium-rich foods – almonds, pumpkin seeds, dark leafy greens, and dark chocolate – a mineral critical for ATP production
  • Minimize alcohol, which disrupts sleep, depletes B vitamins, and drives systemic inflammation
  • Eat breakfast – skipping it creates a prolonged fasting state that lowers morning cortisol inappropriately and impairs both physical and cognitive performance

6. Dehydration – The Overlooked Energy Thief

Dehydration is one of the most frequently overlooked causes of daytime fatigue. When blood volume drops – even by 1-2% of body weight – the heart must work harder to circulate oxygen to tissues, blood pressure falls, and the brain receives marginally less perfusion. The subjective experience of this physiological state is fatigue, difficulty concentrating, and low mood – often mistaken for mental burnout or inadequate sleep.

Research published in the Journal of Nutrition found that even mild dehydration – well before thirst appears – significantly impaired mood, concentration, and perceived task difficulty in otherwise healthy adults. The thirst mechanism becomes less reliable with age, making older adults particularly vulnerable to chronic subclinical dehydration.

What to do:

  • Aim for 8-10 cups of water daily – more during heat, exercise, or illness
  • Start every morning with a large glass of water before coffee
  • Urine color is a reliable marker – pale yellow indicates adequate hydration; dark amber signals dehydration
  • Include water-rich foods – cucumber, watermelon, celery, and leafy greens contribute meaningfully to daily fluid intake
  • Limit alcohol and excess caffeine – both accelerate fluid loss through diuresis

7. Excessive Alcohol and Caffeine Dependency

Both alcohol and caffeine have complex, dose-dependent relationships with energy – and both are commonly used in ways that worsen fatigue over time.

Alcohol is a central nervous system depressant that fragments sleep architecture, suppresses REM sleep, and causes early morning awakening as its sedative effects wear off. It depletes B vitamins – particularly thiamine and B12 – drives systemic inflammation, and disrupts the gut microbiome in ways that impair nutrient absorption. People who drink regularly and feel persistently tired are often experiencing the cumulative effects of sleep disruption and nutritional depletion that alcohol creates nightly.

Caffeine dependency is equally problematic. Caffeine blocks adenosine receptors – the brain’s fatigue-signaling system – providing temporary alertness while allowing adenosine to accumulate. When the caffeine wears off, the accumulated adenosine floods the receptors, producing a deeper fatigue than existed before. Over time, the body upregulates adenosine receptor density in response to chronic caffeine consumption, requiring progressively more caffeine to achieve the same alertness – while baseline fatigue rises.

What to do:

  • Limit alcohol to no more than 1-2 standard drinks per occasion and avoid consecutive nights
  • Keep caffeine intake below 400mg daily and consistent – variation drives withdrawal fatigue
  • Avoid caffeine after 2 PM – its half-life of 5-6 hours means late caffeine still disrupts sleep architecture
  • Consider a 2-week caffeine taper to reset adenosine receptor sensitivity if dependency has developed

8. Lack of Natural Light and Vitamin D Synthesis

Sunlight exposure is one of the most powerful regulators of the circadian rhythm and vitamin D status – two systems with direct and profound effects on energy. Morning bright light activates the suprachiasmatic nucleus (SCN), the brain’s master circadian clock, suppressing melatonin production and triggering the cortisol awakening response that sets the body’s alertness and energy tone for the day.

In modern life – particularly in winter months or for those who work indoors – light exposure is inadequate to fully entrain the circadian clock. The result is a blunted cortisol awakening response, dysregulated melatonin timing, and the low, flat energy profile that many people mistake for constitutional tiredness.

Seasonal affective disorder (SAD), while a distinct diagnosis, exists on a spectrum – and its subclinical form, characterized by low energy, increased sleep, carbohydrate craving, and reduced motivation in winter, is experienced by a far larger proportion of the population than clinical SAD statistics suggest.

What to do:

  • Get 20-30 minutes of outdoor exposure within the first hour of waking – even on overcast days
  • Consider a 10,000 lux light therapy lamp for 20-30 minutes each morning during winter months
  • Check vitamin D levels and supplement if below optimal (generally 50-80 nmol/L is the functional target)
  • Keep indoor workspaces as bright as possible – light intensity drives alertness independently of circadian effects

9. Mental Health Factors – Anxiety, Depression, and Emotional Exhaustion

Anxiety and depression are among the most common medical causes of persistent fatigue – and among the most frequently unrecognized, particularly in individuals who present the fatigue as a physical complaint rather than a mood one. Both conditions disrupt sleep, elevate inflammatory cytokines, impair neurotransmitter function, and reduce the motivation and capacity for physical activity – creating a compounding cycle of worsening energy.

Chronic low-grade depression in particular is characterized by fatigue as its primary symptom – often more prominent than sadness. It is widely underdiagnosed because neither the patient nor their clinician connects persistent tiredness with mood disorder. Emotional exhaustion from burnout – a state of depletion driven by sustained work or caregiving demands with insufficient recovery – shares many features with clinical depression and is associated with the same pattern of inflammatory activation, HPA dysregulation, and mitochondrial impairment.

What to do:

  • If fatigue is accompanied by low mood, poor motivation, loss of interest, or feeling overwhelmed, speak with a healthcare professional
  • Physical exercise is one of the most evidence-backed interventions for both depression and burnout-related fatigue – begin with short, achievable bouts
  • Social connection, nature exposure, and meaningful activity have measurable anti-fatigue effects independent of clinical treatment
  • Adaptogenic and neuroprotective herbal support can provide a meaningful physiological foundation for recovery

The Role of Traditional Medicine in Addressing Chronic Fatigue

Traditional Chinese and Vietnamese Medicine have recognized and treated chronic fatigue patterns for centuries – long before modern medicine developed the biochemical framework to explain them. In TCM, the condition is broadly described as “Qi and Blood deficiency” – a state in which the body’s vital energy is depleted, circulation is insufficient, and the organs lack the nourishment needed to sustain vitality.

This framework maps remarkably closely onto modern understanding. “Qi deficiency” aligns with mitochondrial insufficiency and poor oxygenation. “Blood deficiency” aligns with iron deficiency and anemia. The TCM approach to treatment targets both simultaneously through adaptogenic herbs, blood-nourishing botanicals, and lifestyle interventions.

Several traditional herbs have now been validated through modern clinical research:

  • Dangshen (Codonopsis pilosula) – a premier TCM Qi tonic, shown in studies to enhance red blood cell production, improve hemoglobin levels, reduce physical and mental fatigue, and support immune resilience. Its polysaccharides promote mitochondrial function and adapt the HPA axis to stressors. Find out more about Dangshen’s adaptogenic benefits on SVKHerbal.
  • Fructus Lycii (Goji berry) – rich in polysaccharides, betaine, and zeaxanthin. Shown to improve antioxidant enzyme activity, reduce fatigue markers, and support adrenal and immune function.
  • Ginger extract – in TCM, classified as a warming circulatory herb. Modern evidence confirms its ability to improve peripheral blood flow, reduce systemic inflammation, and counteract the fatigue associated with poor circulation.
  • Radix Glycyrrhizae (Licorice root) – supports adrenal function, modulates cortisol output, and helps stabilize energy levels during periods of chronic stress. Find out more about licorice root’s role in stress and energy support on SVKHerbal.
  • Achyranthes bidentata and Schisandra chinensis – herbs used in the Naturem™ Stamina formulation, supporting circulation, adrenal resilience, and mitochondrial energy output in people experiencing physical and mental exhaustion.

Naturem™ Stamina is formulated with over 20 traditional herbs including Cuscuta hygrophilae, Fructus Lycii, Rehmannia glutinosa, and Schisandra – addressing the multilayered root causes of chronic fatigue from the inside out. When paired with the lifestyle corrections outlined above, botanical support of this depth provides a genuinely synergistic recovery pathway.

Find out more about traditional herbs for blood and energy support in this in-depth article on SVKHerbal.

A Practical Diagnostic Approach: Where to Start

When fatigue is persistent – lasting more than four weeks without an obvious acute cause – it warrants systematic investigation rather than guessing. A structured approach:

Step 1 – Request targeted blood work:

  • Ferritin, serum iron, and TIBC – the most sensitive early markers of iron status
  • Full blood count – hemoglobin, MCV (mean cell volume)
  • Serum B12 and folate
  • Vitamin D (25-OH)
  • Thyroid function (TSH, Free T4) – hypothyroidism is a common and treatable cause of fatigue
  • Fasting glucose and HbA1c – blood sugar dysregulation is a major but frequently unrecognized fatigue driver
  • C-reactive protein (CRP) – a marker of systemic inflammation

Step 2 – Audit your lifestyle honestly: Use a one-week sleep diary, a food log, an activity tracker, and a daily stress and mood journal. Most people are surprised by what the data reveals – average sleep time shorter than believed, more refined carbohydrates than remembered, far less movement than felt.

Step 3 – Implement the highest-leverage changes first: Sleep consistency and quality, adequate protein and iron intake, and daily movement are the three interventions with the fastest and most reliable effects on energy. Begin there and layer in additional strategies over subsequent weeks.

Step 4 – Add targeted natural support: Where nutritional gaps are confirmed or lifestyle change is taking time to produce results, targeted supplementation – both conventional (iron, B12, vitamin D) and botanical (adaptogens, blood-nourishing herbs) – provides a meaningful bridge to restored vitality.

When To See a Doctor

Most lifestyle-driven fatigue responds to the strategies outlined above within 4-8 weeks. However, certain features require prompt medical evaluation:

  • Fatigue lasting more than six months without clear cause – possible myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
  • Fatigue with unintentional weight loss, night sweats, or swollen lymph nodes
  • Fatigue with breathlessness, chest pain, or palpitations
  • Fatigue with progressive neurological symptoms – weakness, numbness, or vision changes
  • Fatigue that is worse after exertion rather than better (post-exertional malaise)
  • Severe or sudden onset fatigue in someone with no prior pattern

These presentations require exclusion of serious underlying pathology before lifestyle interventions are pursued.

The Bottom Line

Feeling tired all the time is not an inevitable feature of modern life. In the overwhelming majority of cases, it reflects a specific, identifiable, and reversible imbalance in how the body is being fueled, rested, moved, and supported.

The most impactful steps – fixing sleep quality, correcting nutritional deficiencies (especially iron and protein), reducing chronic stress, moving daily, stabilizing blood sugar, and hydrating adequately – are free, well-evidenced, and within reach for most people.

Layer in traditional botanical support from clinically validated herbs, and the pathway from chronic exhaustion to sustainable energy becomes both practical and powerful.

Your body is not designed to run on empty. Give it what it needs – and it will show you what it is capable of.

This article is for informational purposes only and does not constitute medical advice. If you experience persistent, worsening, or unexplained fatigue, please consult a qualified healthcare professional.

Frequently Asked Questions (FAQs)

Why am I always tired even after sleeping 8 hours?

Sleeping eight hours does not guarantee restorative rest. Sleep quality and architecture – the depth of deep NREM and REM phases – matter as much as duration. A disrupted circadian rhythm from inconsistent bedtimes, late-night screens, or alcohol prevents the brain from reaching the deep restorative phases where cellular repair, glymphatic waste clearance, and neurotransmitter synthesis occur. Beyond sleep, the most common hidden causes of tiredness despite adequate sleep hours are iron deficiency – where low hemoglobin reduces oxygen delivery to cells – vitamin D deficiency, hypothyroidism, and chronic low-grade stress maintaining cortisol at levels that prevent full physiological recovery overnight. A targeted blood panel covering ferritin, B12, vitamin D, TSH, and full blood count is the most practical first step. (Healthline, 2026)

Can what I eat cause chronic fatigue?

Yes – significantly and directly. Diets high in refined carbohydrates produce rapid insulin spikes followed by reactive hypoglycemia – the blood sugar crash that causes mid-afternoon energy collapse. Simultaneously, heavily processed diets are low in the B vitamins, magnesium, and CoQ10 required for mitochondrial ATP production – the molecular currency of cellular energy. Protein deficiency is particularly impactful: without adequate amino acids, the body cannot synthesize dopamine, serotonin, or norepinephrine – neurotransmitters that underpin both physical energy and mental motivation. A 2019 NIH-cited study confirmed that high-fat, low-nutrient diets combined with sedentary behavior significantly elevate oxidative stress biomarkers, directly impairing cellular energy output. Replacing refined carbohydrates with complex whole foods, prioritizing protein at every meal, and ensuring iron-rich food intake are the highest-impact dietary changes for fatigue. (Penn State Health, 2025)

Does stress really cause physical fatigue?

Yes – through multiple well-documented biological pathways. Chronic stress activates the HPA axis and maintains elevated cortisol, which over time depletes neurotransmitter precursors, disrupts sleep architecture, drives systemic neuroinflammation, and impairs mitochondrial function – the energy-producing organelles in every cell. This is not metaphorical tiredness; it is a measurable reduction in cellular ATP output. A study published in Psychotherapy and Psychosomatics found that 65% of sedentary adults who began a moderate exercise program reported significant fatigue reduction – reflecting both the anti-stress and pro-mitochondrial effects of physical activity. Adaptogenic herbs such as Dangshen and Schisandra directly modulate HPA axis reactivity and support adrenal recovery, providing a complementary physiological foundation alongside stress management practices. (BHF, 2025)

How can traditional herbs help with chronic fatigue?

Traditional Chinese and Vietnamese medicine have documented and treated fatigue patterns for centuries under the framework of “Qi and Blood deficiency” – states that correspond closely to modern understanding of mitochondrial insufficiency and iron deficiency anemia. Several key herbs are now validated by modern clinical research. Dangshen (Codonopsis pilosula) improves red blood cell production, enhances hemoglobin levels, and reduces physical and mental fatigue through its polysaccharide and alkaloid content. Schisandra chinensis, a key ingredient in Naturem™ Stamina, has been shown to balance cortisol, improve exercise capacity, and reduce fatigue through adaptogenic mechanisms. Fructus Lycii (Goji berry) improves antioxidant enzyme activity and supports adrenal function. These herbs work best as a consistent daily foundation, not as acute rescue remedies – most people report measurable improvement in energy within 2-4 weeks of consistent use. (Luan et al., 2021)

When should I see a doctor about fatigue?

While most lifestyle-driven fatigue responds to the strategies in this article within 4-8 weeks, certain presentations require urgent medical evaluation rather than self-management. See a doctor promptly for fatigue accompanied by unintentional weight loss, night sweats, swollen lymph nodes, breathlessness, chest pain, or palpitations. Seek evaluation for fatigue that is progressively worsening over weeks, present after minimal exertion, or unresponsive to six weeks of consistent lifestyle improvement. A complete blood count with iron studies, thyroid function panel (TSH, Free T4), vitamin D, fasting glucose, and C-reactive protein covers the most common reversible causes and should be requested at the same time rather than sequentially. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) – characterized by post-exertional malaise, unrefreshing sleep, and cognitive dysfunction lasting more than six months – is a distinct medical condition requiring specialist evaluation and should not be managed as general lifestyle fatigue. (Baton Rouge Clinic, 2026)

References:

Bai, Y., Zhao, J., & Wang, C. (2020). Cognitive benefits of Codonopsis extract on memory and cerebral circulation. Food & Function, 11(3), 2422-2432. https://doi.org/10.1039/c9fo02969a

British Heart Foundation. (2025). Why am I always tired? https://www.bhf.org.uk/informationsupport/heart-matters-magazine/medical/why-am-i-always-tired

Centers for Disease Control and Prevention. (2024). Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). https://www.cdc.gov/me-cfs/index.html

Healthline. (2026). 12 reasons you’re always tired (and what to do about it). https://www.healthline.com/nutrition/10-reasons-you-are-tired

Luan, F., He, X., & Zeng, N. (2021). Bioactive polysaccharides from Codonopsis pilosula and their pharmacological activities. Carbohydrate Polymers, 268, 117863. https://doi.org/10.1016/j.carbpol.2021.117863

MedlinePlus. (2024). Fatigue: MedlinePlus medical encyclopedia. U.S. National Library of Medicine. https://medlineplus.gov/ency/article/003088.htm

National Institute of Diabetes and Digestive and Kidney Diseases. (2024). Hypothyroidism. https://www.niddk.nih.gov/health-information/endocrine-diseases/hypothyroidism

Penn State Health. (2025). The medical minute: Why am I always so tired? https://pennstatehealthnews.org/2025/03/the-medical-minute-why-am-i-always-so-tired/

Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017). Oxidative stress: Harms and benefits for human health. Oxidative Medicine and Cellular Longevity, 2017, 8416763. https://doi.org/10.1155/2017/8416763

Puetz, T. W., Flowers, S. S., & O’Connor, P. J. (2008). A randomized controlled trial of the effect of aerobic exercise training on feelings of energy and fatigue in sedentary young adults with persistent fatigue. Psychotherapy and Psychosomatics, 77(3), 167-174. https://doi.org/10.1159/000116610

Regehr, J. (2025). Fatigue. In R. D. Kellerman, J. J. Heidelbaugh, & E. M. Lee (Eds.), Conn’s Current Therapy 2025 (pp. 13-14). Elsevier.

World Health Organization. (2023). Anaemia. https://www.who.int/news-room/fact-sheets/detail/anaemia

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